Hot Flashes Treatment
If hot flashes are affecting your quality of life and you’re unable or not willing to take Hormone Replacement Therapy (HRT), PRP Ovarian Rejuvenation may help your body produce its own hormones by reactivating your ovaries.
RFC is one of the first centers in the world to pioneer and publish about PRP ovarian rejuvenation. PRP ovarian rejuvenation is a minimally invasive procedure designed to support ovarian function especially after menopause. As of today, there are over 170 medical publications about PRP administration into the ovaries.
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What Are Hot Flashes?
Hot flashes are sudden episodes of intense warmth, most commonly felt in the face, neck, and chest, often accompanied by: Flushing or redness of the skin, Sweating, Rapid heartbeat, Anxiety or discomfortChills afterwardWhen they occur at night, they are called night sweats and can significantly disrupt sleep.
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Why They Happen
Hot flashes are primarily caused by hormonal fluctuations, especially declining or unstable estrogen levels, which affect the brain’s temperature-regulating center (the hypothalamus).
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When Should a Woman Seek Medical Help?
A woman should seek evaluation if hot flashes:
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Interfere with sleep, work, or quality of life
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Occur frequently or severely
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Are associated with:
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Heart palpitations
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Dizziness or fainting
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Unexplained weight loss
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Fever or night sweats unrelated to menopause
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Begin unexpectedly or at a young age
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Are accompanied by other menopausal symptoms (mood changes, vaginal dryness, low libido)
Hot flashes should not automatically be dismissed as “normal” if they are disruptive or concerning.
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How Are Hot Flashes Evaluated?
Evaluation may include:
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Medical history and symptom review
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Menstrual and reproductive history
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Hormonal testing (as appropriate)
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Thyroid function testing
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Review of medications and lifestyle factors
When Do Hot Flashes Occur?
They most commonly occur during:
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Perimenopause (the years leading up to menopause)
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Menopause (defined as 12 months without a menstrual period)
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Postmenopause
They can also occur with:
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Surgical menopause (ovary removal)
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Certain medications (e.g., anti-estrogen therapies)
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Chemotherapy or radiation
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Severe stress or illness
What Are the Potential Treatments?
Treatment is individualized and depends on symptom severity, medical history, and patient preferences.
Lifestyle & Behavioral Strategies (First-Line for Mild Symptoms)
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Dressing in layers
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Avoiding triggers (spicy foods, alcohol, caffeine)
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Cooling techniques
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Stress reduction and sleep optimization
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Regular physical activity
Supplements & Integrative Approaches
May help some women, though evidence varies:
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Magnesium
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Vitamin D (if deficient)
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Herbal supplements (used cautiously and with guidance)
Hormonal Therapy (Most Effective for Many Women)
Menopausal Hormone Therapy (MHT) may include:
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Estrogen (with or without progesterone, depending on uterine status)
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Various formulations: oral, transdermal, vaginal
Benefits:
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Most effective treatment for hot flashes
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Can also improve sleep, mood, and vaginal symptoms
Hormone therapy should be:
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Carefully individualized
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Prescribed after reviewing risks and benefits
Regenerative & Longevity-Focused Care (Adjunctive)
In selected women:
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Hormonal optimization
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Sleep and metabolic support
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Stress and nervous system regulation
These approaches aim to improve overall physiologic resilience, which may reduce symptom burden.
Non-Hormonal Prescription Medications
For women who cannot or prefer not to use hormones:
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Certain antidepressants (SSRIs/SNRIs)
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Gabapentin
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Clonidine
These may reduce hot flash frequency and severity.
PRP Ovarian Rejuvenation
PRP may lead to modest improvement in ovarian hormonal activity, potentially resulting in:
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More stable estrogen production
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Reduced hormonal fluctuations
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Decreased frequency or severity of hot flashes
The effect of PRP lasts up to 3 months. If meaningful improvement is not seen, your physician may discuss next steps, including repeating PRP or considering other options such as Adipose-PRP or Stem cells in the Bahamas.
What PRP Ovarian Rejuvenation Does Not Do
Some women pursue ovarian rejuvenation not only for fertility planning, but also for symptom support during hormonal transition. Patients may report improvement in:
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Hot flashes or night sweats
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Sleep quality and fatigue
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Mood changes (anxiety/irritability)
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Low libido or vaginal dryness
These symptom outcomes can vary significantly and should be discussed with your physician. PRP is not guaranteed to treat menopause symptoms.
PRP does not:
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Last forever (it can help for up to 3 months)
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Guarantee estrogen normalization
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Replace hormone therapy
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Reverse menopause
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Consistently eliminate hot flashes
Any improvement in hot flashes should be viewed as a possible secondary benefit, not a primary indication.
Why choose RFC to help you with hot flashes?
At RFC, we approach hot flashes and menopausal symptoms through the lens of reproductive endocrinology and longevity medicine.
Our care is led by specialists who deeply understand the hormonal, ovarian, and neuroendocrine changes that drive these symptoms.
We go beyond symptom suppression by offering comprehensive evaluations, advanced hormonal testing, and individualized treatment plans that may include hormone optimization, non-hormonal therapies, and regenerative approaches when appropriate.
Our goal is not just temporary relief, but restoring balance, improving quality of life, and supporting women through every stage of reproductive aging with evidence-based, compassionate care.
Frequently asked questions
What is ovarian rejuvenation?
Ovarian rejuvenation is a cutting-edge fertility procedure intended to reawaken egg maturation and development within the ovary and potentially improve egg quality, especially in women over 40, women with diminished ovarian reserve (DOR), low AMH, high FSH, premature ovarian insufficiency (POI), or early menopause. Women always have eggs inside their ovaries, but many of these eggs are dormant.
Does ovarian rejuvenation work for women in menopause or very low ovarian reserve?
Women with diminished ovarian reserve (DOR) and even postmenopausal women with anti-Mullerian hormone (AMH) of 0 (ZERO) still have on average 1,000 dormant eggs inside their ovaries. Ovarian rejuvenation is a newly pioneered procedure intended to reawaken egg maturation and development within the ovary and potentially improve egg quality, especially in women with low egg count or women over 40 with diminished ovarian reserve (DOR).
Are there studies to support ovarian rejuvenation?
There are OVER 160 peer-reviewed publications on PubMed showing that rejuvenation therapy could be used to achieve pregnancy in women with low ovarian reserve or diminished ovarian reserve (DOR), women with premature ovarian insufficiency (POI), and women with early menopause.
Is PRP ovarian rejuvenation widely available?
Rejuvenating Fertility Center is:
The FIRST in the Northeast to pioneer PRP (Platelet-Rich Plasma) ovarian rejuvenation
The FIRST IN THE WORLD to offer Adipose-PRP ovarian rejuvenation
As leaders in ovarian rejuvenation for women with diminished ovarian reserve (DOR), with several peer-reviewed publications, RFC performs intraovarian injections using the patient’s own platelets, plasma, and fat stem cells to stimulate egg production at any age, even after the onset of menopause.
How many types of ovarian rejuvenation are there?
There are two types of ovarian rejuvenation that can be performed in the United States:
PRP (Platelet-Rich Plasma) ovarian rejuvenation
Adipose-PRP ovarian rejuvenation
There are over 160 peer-reviewed publications on PubMed about ovarian rejuvenation.
Why doesn’t ovarian rejuvenation work all the time?
Ovarian rejuvenation is still considered an emerging treatment. Outcomes vary, and success is not guaranteed. PRP or Adipose-PRP might not work for everyone for unknown reasons. Success depends on:
How the procedure is performed
Amount of PRP or Adipose-PRP injected
Number of injections per ovary
Needle size and technique
Exact injection sites
Post-procedure medications and protocol
Proper protocol after ovarian rejuvenation is 50% of the key to success.
What are the side effects of ovarian rejuvenation?
Possible side effects include:
Common (usually mild and short-lived): Pelvic cramping, spotting, transient discomfort, vasovagal symptoms.
Procedure-related (rare): Infection, bleeding, ovarian or pelvic abscess, injury to nearby structures, anesthesia reactions.
PRP-specific: Contamination risk if sterility is compromised; local inflammation or fever reported in other PRP applications.
Can ovarian rejuvenation improve symptoms besides fertility?
Ovarian rejuvenation can help improve hormonal imbalances and menopausal symptoms such as:
Mood swings, anxiety, or depression
Weight changes
Dry or oily skin
Hair thinning or hair loss
Hot flashes or night sweats
Low libido or vaginal dryness
Sleep troubles or fatigue
Has RFC had success using ovarian rejuvenation?
RFC has helped the oldest woman in the USA get pregnant using her own eggs at age 51 following ovarian rejuvenation and IVF. RFC has also helped the highest number of women in their late 40s and early 50s achieve pregnancy using their own eggs.
Why choose Rejuvenating Fertility Center for ovarian rejuvenation?
Dr. Merhi was:
The FIRST in the Northeast to offer PRP ovarian rejuvenation
The FIRST in the USA and WORLD to offer Adipose-PRP ovarian rejuvenation
RFC combines personalized protocols, advanced techniques, extensive research, and affordability, reporting IVF success rates that surpass national averages.
OVARIAN REJUVENATION SUCCESS RATES AND RESEARCH FROM RFC:
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Zaher Merhi and Marco Mouanness. Intraovarian platelet-rich plasma administration could improve blastocyst euploidy rates in women undergoing in vitro fertilization. Clin Exp Reprod Med. 2022;49:210-214.
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Zaher Merhi and Marco Mouanness. Intraovarian Platelet-Rich Plasma administration Induced Spontaneous Ovulation in an Anovulatory Woman with PCOS. JCEM Case Reports. 2023;21;1:38.
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Zaher Merhi and Marco Mouanness. Intraovarian PRP Injection Improved Hot Flashes in a Woman With Very Low Ovarian Reserve. Reprod Sci. 2022;29:614-619.
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Marco Mouanness and Zaher Merhi and. Use of Intra-uterine Injection of Platelet-rich Plasma (PRP) for Endometrial Receptivity and Thickness: a Literature Review of the Mechanisms of Action. Reprod Sci. 2021;28:1659-1670.
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Zaher Merhi and Marco Mouanness. Ovarian response to intraovarian platelet-rich plasma (PRP) administration: hypotheses and potential mechanisms of action. J Assist Reprod Genet. 2022;39:37-61.
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Zaher Merhi, Catrina Wiltshire McLeod, Fawziyah Shamim. Platelet-Rich Plasma in Reproductive Endocrinology: Mechanisms and Clinical Applications for Ovarian Reserve, PCOS, and Endometrial Receptivity. Biomedicines. 2025 Oct 13;13(10):2488.