
Vaginal Rejuvenation
with PRP (Platelet-Rich Plasma)
If you struggle with low sex desire and sexual response is thought to be influenced by local tissue, vascular, or neurologic factors, rather than psychological causes alone, then Vaginal Rejuvenation is for you
RFC is one of the first centers in the world to pioneer and publish about PRP rejuvenation. As of today, there are over 170 medical publications about PRP administration.
What is Vaginal PRP Rejuvenation?
Vaginal PRP rejuvenation is a non-surgical regenerative treatment that uses a patient’s own platelet-rich plasma (PRP) to support vaginal and vulvar tissue health, blood flow, and sensitivity. It is most commonly offered as part of sexual wellness, menopausal care, or longevity-focused gynecology and is considered an adjunctive, investigational therapy.
Vaginal PRP rejuvenation involves injecting PRP into specific vaginal and/or vulvar tissues to help:
-
Improve tissue quality and elasticity
-
Enhance local blood flow
-
Support nerve sensitivity
-
Reduce vaginal dryness or discomfort
-
Improve sexual responsiveness in selected patients
What is PRP?
PRP stands for platelet-rich plasma, a concentrated component of your own blood that contains growth factors that improve cellular health. In ovarian rejuvenation, PRP is carefully prepared and delivered to the uterus via infusion or injections (under hysteroscopy guidance) approach.

Common Reasons Patients Seek Vaginal PRP
Vaginal PRP may be considered for women experiencing:
-
Reduced sexual arousal or responsiveness
-
Postpartum or menopausal vaginal changes
Potential Candidates For Vaginal PRP Rejuvenation
Women With Low Sexual Desire or Reduced Sexual Response
Reduced Genital Sensitivity
Hormonal Transitions or Hormonal Changes
Women Seeking Regenerative or Sexual Wellness Therapies
Vaginal or Vulvar Tissue Changes
Vaginal or Vulvar Dryness
How Is It Performed?
-
A small blood sample is drawn and processed to create PRP (40 minutes)
-
Local or topical anesthesia is applied for comfort
-
PRP is injected with a fine needle into targeted vaginal or vulvar areas
-
The procedure is typically completed in 15–30 minutes in the office

Safety and Limitations
-
Uses the patient’s own blood, minimizing allergy risk
-
Mild swelling or tenderness may occur temporarily
-
Infection risk is low when sterile technique is used
-
Clinical evidence is limited and evolving
-
Results vary and are not guaranteed
Who Is Not an Ideal Candidate
Use of Vaginal PRP is not recommended for women with:
-
Active vaginal or pelvic infection
-
Untreated vulvar or vaginal lesions
-
Known gynecologic malignancy
-
Bleeding disorders or anticoagulation that cannot be managed
-
Predominantly psychological or relationship-based causes of low libido without addressing those factors
Best Outcomes Occur When Combined With:
-
Hormonal evaluation and optimization
-
Vaginal health treatments (lubricants, estrogen if appropriate)
-
Lifestyle and relationship considerations
-
Counseling when indicated
Frequently asked questions
How does vaginal PRP rejuvenation compare to laser vaginal rejuvenation?
Vaginal PRP and laser rejuvenation work through different mechanisms. PRP uses your own concentrated platelets and growth factors injected into vaginal and vulvar tissue to stimulate regeneration from within — promoting new cell growth, collagen production, and improved blood flow at a cellular level. Laser treatments (such as fractional CO2 laser) work by creating controlled micro-injuries on the vaginal wall surface that trigger a healing response. Both can improve dryness, tissue quality, and sensitivity. PRP is fully autologous (no external device or energy), while laser requires specialized equipment. Some providers combine both for enhanced results. Your RFC physician can discuss which approach, or combination, is best suited to your symptoms.
How many vaginal PRP sessions are needed, and how long do results last?
Most patients begin to notice improvements within 2 to 3 weeks after the first vaginal PRP session as the growth factors stimulate tissue regeneration. Results typically continue developing over the following weeks to months. Many patients benefit from 1 to 2 initial treatments, with maintenance sessions recommended approximately every 6 to 12 months depending on individual response. Results are not permanent because vaginal tissue continues to change with age and hormonal status, but ongoing PRP treatments can sustain improvements in lubrication, sensitivity, and tissue health over time.
Is vaginal PRP rejuvenation only for menopausal women, or can it help after childbirth too?
Vaginal PRP rejuvenation is not limited to menopausal women. It can also help women experiencing vaginal changes after childbirth, including reduced sensation, tissue laxity, dryness, or discomfort during intercourse. Childbirth can stretch and affect vaginal tissue, and PRP supports the body's natural repair process by promoting collagen production, improving blood flow, and enhancing tissue elasticity. Women at any adult age who are experiencing vaginal health changes — whether from menopause, postpartum recovery, hormonal shifts, or breastfeeding — may be candidates.
Can vaginal PRP help with mild urinary incontinence?
Vaginal PRP may provide benefit for women experiencing mild stress urinary incontinence — the type that causes leakage during coughing, sneezing, laughing, or exercise. PRP's growth factors can support tissue strengthening and improved blood flow in the vaginal and periurethral areas, which may help improve bladder control. It is most effective when combined with other approaches such as pelvic floor exercises, hormonal optimization, and lifestyle modifications. PRP is not a replacement for surgical treatment in cases of severe incontinence, but it can be a valuable non-surgical option for mild to moderate symptoms.
Is vaginal rejuvenation related to fertility treatment, or is it a separate procedure?
Vaginal PRP rejuvenation is a separate procedure from fertility-focused treatments like ovarian or uterine rejuvenation. It is a sexual wellness and gynecologic health treatment, not an infertility procedure. Vaginal PRP targets the vaginal and vulvar tissues to improve dryness, sensitivity, comfort during intercourse, and tissue quality — it does not affect egg production, endometrial receptivity, or pregnancy rates. However, RFC offers vaginal rejuvenation alongside its fertility services because many patients dealing with hormonal changes, menopause, or postpartum recovery have overlapping needs. Your doctor can coordinate both types of care if needed.
UTERINE REJUVENATION SUCCESS RATES AND RESEARCH FROM RFC:
-
Marco Mouanness and Zaher Merhi and. Use of Intra-uterine Injection of Platelet-rich Plasma (PRP) for Endometrial Receptivity and Thickness: a Literature Review of the Mechanisms of Action. Reprod Sci. 2021;28:1659-1670.
-
Zaher Merhi, Catrina Wiltshire McLeod, Fawziyah Shamim. Platelet-Rich Plasma in Reproductive Endocrinology: Mechanisms and Clinical Applications for Ovarian Reserve, PCOS, and Endometrial Receptivity. Biomedicines. 2025 Oct 13;13(10):2488.
-
Zaher Merhi. Clinical practice perspectives on adipose-derived stem cells and platelet-rich plasma for female infertility treatments. Future Sci OA. 2025 Dec;11(1):2580233.
-
Zaher Merhi, Bhavika Garg, Jessica Haroun. Endocrine and regenerative mechanisms of adipose-derived stem cells in female infertility. Front Endocrinol (Lausanne). 2025 Oct 21:16:1694025
