Vaginal Rejuvenation
with PRP (Platelet-Rich Plasma)
If you struggle with low sex desire and sexual response is thought to be influenced by local tissue, vascular, or neurologic factors, rather than psychological causes alone, then Vaginal Rejuvenation is for you
RFC is one of the first centers in the world to pioneer and publish about PRP rejuvenation. As of today, there are over 170 medical publications about PRP administration.
What is vaginal PRP rejuvenation?
Vaginal PRP rejuvenation is a non-surgical regenerative treatment that uses a patient’s own platelet-rich plasma (PRP) to support vaginal and vulvar tissue health, blood flow, and sensitivity. It is most commonly offered as part of sexual wellness, menopausal care, or longevity-focused gynecology and is considered an adjunctive, investigational therapy.
Vaginal PRP rejuvenation involves injecting PRP into specific vaginal and/or vulvar tissues to help:
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Improve tissue quality and elasticity
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Enhance local blood flow
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Support nerve sensitivity
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Reduce vaginal dryness or discomfort
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Improve sexual responsiveness in selected patients
What is PRP?
PRP stands for platelet-rich plasma, a concentrated component of your own blood that contains growth factors that improve cellular health. In ovarian rejuvenation, PRP is carefully prepared and delivered to the uterus via infusion or injections (under hysteroscopy guidance) approach.
The goal is to support your uterus for implantation and to lower miscarriage and chemical pregnancy risks.
Common Reasons Patients Seek Vaginal PRP
Vaginal PRP may be considered for women experiencing:
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Reduced sexual arousal or responsiveness
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Postpartum or menopausal vaginal changes
Potential Candidates For Vaginal PRP Rejuvenation
Women With Low Sexual Desire or Reduced Sexual Response
Reduced Genital Sensitivity
Hormonal Transitions or Hormonal Changes
Women Seeking Regenerative or Sexual Wellness Therapies
Vaginal or Vulvar Tissue Changes
Vaginal or Vulvar Dryness
How Is It Performed?
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A small blood sample is drawn and processed to create PRP (40 minutes)
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Local or topical anesthesia is applied for comfort
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PRP is injected with a fine needle into targeted vaginal or vulvar areas
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The procedure is typically completed in 15–30 minutes in the office
Safety and Limitations
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Uses the patient’s own blood, minimizing allergy risk
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Mild swelling or tenderness may occur temporarily
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Infection risk is low when sterile technique is used
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Clinical evidence is limited and evolving
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Results vary and are not guaranteed
Who Is Not an Ideal Candidate
Use of Vaginal PRP is not recommended for women with:
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Active vaginal or pelvic infection
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Untreated vulvar or vaginal lesions
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Known gynecologic malignancy
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Bleeding disorders or anticoagulation that cannot be managed
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Predominantly psychological or relationship-based causes of low libido without addressing those factors
Best Outcomes Occur When Combined With:
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Hormonal evaluation and optimization
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Vaginal health treatments (lubricants, estrogen if appropriate)
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Lifestyle and relationship considerations
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Counseling when indicated
UTERINE REJUVENATION SUCCESS RATES AND RESEARCH FROM RFC:
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Marco Mouanness and Zaher Merhi and. Use of Intra-uterine Injection of Platelet-rich Plasma (PRP) for Endometrial Receptivity and Thickness: a Literature Review of the Mechanisms of Action. Reprod Sci. 2021;28:1659-1670.
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Zaher Merhi, Catrina Wiltshire McLeod, Fawziyah Shamim. Platelet-Rich Plasma in Reproductive Endocrinology: Mechanisms and Clinical Applications for Ovarian Reserve, PCOS, and Endometrial Receptivity. Biomedicines. 2025 Oct 13;13(10):2488.
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Zaher Merhi. Clinical practice perspectives on adipose-derived stem cells and platelet-rich plasma for female infertility treatments. Future Sci OA. 2025 Dec;11(1):2580233.
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Zaher Merhi, Bhavika Garg, Jessica Haroun. Endocrine and regenerative mechanisms of adipose-derived stem cells in female infertility. Front Endocrinol (Lausanne). 2025 Oct 21:16:1694025