PRP Ovarian Rejuvenation (Platelet-Rich Plasma)
If you were told that you have no eggs (because you have menopause or POI) or your eggs are bad quality because you are over 40, PRP Ovarian Rejuvenation could help you have babies using your own eggs and avoid Donor Eggs.
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RFC is one of the first centers in the world to pioneer and publish about PRP ovarian rejuvenation.
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PRP ovarian rejuvenation is a minimally invasive procedure designed to support ovarian function and potentially improve ovarian response—especially for women:
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Over 40 years old
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Diminished ovarian reserve (DOR) such as low AMH or high FSH
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Poor egg or embryo quality
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Previously failed IVF
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Premature ovarian insufficiency (POI)
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Early menopause
NOTE: As of today, there are over 170 medical publications about PRP administration into the ovaries (many are published by RFC and Dr Merhi).
What is PRP ovarian rejuvenation?
PRP stands for platelet-rich plasma, a concentrated component of your own blood that contains growth factors that are good for the eggs.
Many women still have dormant follicles in the ovaries—even when AMH is 0 [zero]. PRP ovarian rejuvenation is intended to help "activate" ovarian function and improve the quality of ovarian response in select cases.
In ovarian rejuvenation, PRP is carefully prepared and delivered to the ovaries via vaginal approach, under ultrasound guidance. The goal is to support the ovarian environment and encourage healthier follicular activity in appropriate candidates.
Who is a candidate for PRP ovarian rejuvenation?
PRP ovarian rejuvenation may be considered for women who want to pursue pregnancy using their own eggs and who have signs of reduced ovarian function, such as:
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Diminished Ovarian Reserve (DOR)
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Very Low AMH (even if it is ZERO)
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Very High FSH (even if it is over 100)
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Poor egg quality or poor embryo quality
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Poor response to conventional, traditional aggressive IVF stimulation
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Premature Ovarian Insufficiency (POI)
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Early menopause
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Hormonal imbalance symptoms affecting quality of life
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Menopausal symptoms (such as hot flashes and vaginal dryness)
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Low libido
How the PRP ovarian rejuvenation procedure works
PRP ovarian rejuvenation at RFC is designed to be efficient, structured, and monitored.
Procedure timeline (in-office)
Most patients spend about 1.5 hours at the clinic.
Blood draw
(about 5 minutes)
We draw a small amount of blood from your arm.
PRP preparation (about 40 minutes)
Your blood is processed in a controlled setting to concentrate platelets.
PRP delivery (about 15 minutes)
PRP is delivered into the ovaries via a minimally invasive vaginal approach under ultrasound guidance. Comfort measures and anesthesia options are available.
What happens after PRP?
Follow-up is a major part of success. After the procedure, patients typically undergo weekly monitoring for 2–8 weeks, including:
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Blood hormone testing
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Vaginal ultrasound (including follicle count)
PRP's effect starts in 2 weeks after the procedure and its improving effects can last up to ~3 months, during which patients could see improved ovarian response. If meaningful improvement is not seen, your physician may discuss next steps, including repeating PRP or considering other options such as Adipose-PRP or Stem cells in the Bahamas.
Can PRP be combined with IVF or fertility treatment?
Yes. Indeed, PRP Ovarian Rejuvenation Alone is NOT MAGIC... what you do afterwards is as important for the success!
PRP may be used before IVF or alongside other fertility plans, depending on your goal and ovarian profile. Many patients pursue IVF after PRP once monitoring suggests an improved response HOWEVER, WE DO NOT RECOMMEND HIGH DOSES OF IVF MEDICATIONS. Timing is individualized; commonly PRP is performed at least 2+ weeks before an IVF cycle (case dependent).
Some women pursue ovarian rejuvenation not only for fertility planning, but also for symptom support during hormonal transition. Patients may report improvement in:
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Hot flashes or night sweats
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Sleep quality and fatigue
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Mood changes (anxiety/irritability)
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Low libido or vaginal dryness
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Skin and hair changes
These symptom outcomes can vary significantly and should be discussed with your physician. PRP is not guaranteed to treat menopause symptoms.
Why PRP is different at RFC
PRP ovarian rejuvenation is highly technique-dependent and response varies among different clinics. Common reasons for variable outcomes include:
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PRP preparation quality and concentration
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Injection location within the ovaries
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Injection techniques: size of the needle and number of injections per ovary
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Post-procedure protocol and monitoring
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Timing of IVF or stimulation (medication protocols) afterward
At RFC, we emphasize case selection + technique + post-care protocol, not just the procedure.
NOTE: If you have done PRP somewhere other than RFC and you did not see improvement, it does not mean that PRP done at RFC won't work for you (and vice versa).
Side effects and risks
Most patients experience mild, short-term effects such as:
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Temporary pelvic cramping
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Light spotting
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Brief discomfort after the procedure
We review risks, safety steps, and individualized contraindications during your consultation and we provide detailed consent before the procedure.
Why choose RFC for PRP ovarian rejuvenation?
RFC is known for personalized fertility care for women with complex profiles—especially those over 40 or with low ovarian reserve. Our team emphasizes:
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Advanced, minimally invasive fertility procedures
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Individualized stimulation strategy (not one-size-fits-all)
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Research participation and ongoing publication
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Global care experience (many patients travel for treatment)
Frequently asked questions
What is ovarian rejuvenation?
Ovarian rejuvenation is a cutting-edge fertility procedure intended to reawaken egg maturation and development within the ovary and potentially improve egg quality, especially in women over 40, women with diminished ovarian reserve (DOR), low AMH, high FSH, premature ovarian insufficiency (POI), or early menopause. Women always have eggs inside their ovaries, but many of these eggs are dormant.
Does ovarian rejuvenation work for women in menopause or very low ovarian reserve?
Women with diminished ovarian reserve (DOR) and even postmenopausal women with anti-Mullerian hormone (AMH) of 0 (ZERO) still have on average 1,000 dormant eggs inside their ovaries. Ovarian rejuvenation is a newly pioneered procedure intended to reawaken egg maturation and development within the ovary and potentially improve egg quality, especially in women with low egg count or women over 40 with diminished ovarian reserve (DOR).
Are there studies to support ovarian rejuvenation?
There are OVER 160 peer-reviewed publications on PubMed showing that rejuvenation therapy could be used to achieve pregnancy in women with low ovarian reserve or diminished ovarian reserve (DOR), women with premature ovarian insufficiency (POI), and women with early menopause.
Is PRP ovarian rejuvenation widely available?
Rejuvenating Fertility Center is:
The FIRST in the Northeast to pioneer PRP (Platelet-Rich Plasma) ovarian rejuvenation
The FIRST IN THE WORLD to offer Adipose-PRP ovarian rejuvenation
As leaders in ovarian rejuvenation for women with diminished ovarian reserve (DOR), with several peer-reviewed publications, RFC performs intraovarian injections using the patient’s own platelets, plasma, and fat stem cells to stimulate egg production at any age, even after the onset of menopause.
How many types of ovarian rejuvenation are there?
There are two types of ovarian rejuvenation that can be performed in the United States:
PRP (Platelet-Rich Plasma) ovarian rejuvenation
Adipose-PRP ovarian rejuvenation
There are over 160 peer-reviewed publications on PubMed about ovarian rejuvenation.
Why doesn’t ovarian rejuvenation work all the time?
Ovarian rejuvenation is still considered an emerging treatment. Outcomes vary, and success is not guaranteed. PRP or Adipose-PRP might not work for everyone for unknown reasons. Success depends on:
How the procedure is performed
Amount of PRP or Adipose-PRP injected
Number of injections per ovary
Needle size and technique
Exact injection sites
Post-procedure medications and protocol
Proper protocol after ovarian rejuvenation is 50% of the key to success.
What are the side effects of ovarian rejuvenation?
Possible side effects include:
Common (usually mild and short-lived): Pelvic cramping, spotting, transient discomfort, vasovagal symptoms.
Procedure-related (rare): Infection, bleeding, ovarian or pelvic abscess, injury to nearby structures, anesthesia reactions.
PRP-specific: Contamination risk if sterility is compromised; local inflammation or fever reported in other PRP applications.
Can ovarian rejuvenation improve symptoms besides fertility?
Ovarian rejuvenation can help improve hormonal imbalances and menopausal symptoms such as:
Mood swings, anxiety, or depression
Weight changes
Dry or oily skin
Hair thinning or hair loss
Hot flashes or night sweats
Low libido or vaginal dryness
Sleep troubles or fatigue
Has RFC had success using ovarian rejuvenation?
RFC has helped the oldest woman in the USA get pregnant using her own eggs at age 51 following ovarian rejuvenation and IVF. RFC has also helped the highest number of women in their late 40s and early 50s achieve pregnancy using their own eggs.
Why choose Rejuvenating Fertility Center for ovarian rejuvenation?
Dr. Merhi was:
The FIRST in the Northeast to offer PRP ovarian rejuvenation
The FIRST in the USA and WORLD to offer Adipose-PRP ovarian rejuvenation
RFC combines personalized protocols, advanced techniques, extensive research, and affordability, reporting IVF success rates that surpass national averages.
OVARIAN REJUVENATION SUCCESS RATES AND RESEARCH FROM RFC:
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Zaher Merhi and Marco Mouanness. Intraovarian platelet-rich plasma administration could improve blastocyst euploidy rates in women undergoing in vitro fertilization. Clin Exp Reprod Med. 2022;49:210-214.
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Zaher Merhi and Marco Mouanness. Intraovarian Platelet-Rich Plasma administration Induced Spontaneous Ovulation in an Anovulatory Woman with PCOS. JCEM Case Reports. 2023;21;1:38.
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Zaher Merhi and Marco Mouanness. Intraovarian PRP Injection Improved Hot Flashes in a Woman With Very Low Ovarian Reserve. Reprod Sci. 2022;29:614-619.
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Marco Mouanness and Zaher Merhi and. Use of Intra-uterine Injection of Platelet-rich Plasma (PRP) for Endometrial Receptivity and Thickness: a Literature Review of the Mechanisms of Action. Reprod Sci. 2021;28:1659-1670.
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Zaher Merhi and Marco Mouanness. Ovarian response to intraovarian platelet-rich plasma (PRP) administration: hypotheses and potential mechanisms of action. J Assist Reprod Genet. 2022;39:37-61.
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Zaher Merhi, Catrina Wiltshire McLeod, Fawziyah Shamim. Platelet-Rich Plasma in Reproductive Endocrinology: Mechanisms and Clinical Applications for Ovarian Reserve, PCOS, and Endometrial Receptivity. Biomedicines. 2025 Oct 13;13(10):2488.