Ovarian Rejuvenations:
- PRP (platelet-rich plasma)
- Adipose- PRP
What is Ovarian Rejuvenation?
Discover PRP ovarian rejuvenation at RFC – a cutting-edge, non-surgical option to restore ovarian function, improve egg quality, and support fertility for women in New York and beyond.
Women always have eggs inside their ovaries but a lot of these eggs are dormant.
Does Ovarian Rejuvenation work for women in menopause or VERY LOW ovarian reserve?
Even postmenopausal women with anti-Mullerian hormone (AMH) of 0 (ZERO) still have on average 1,000 dormant eggs inside their ovaries. Ovarian rejuvenation is a newly pioneered procedure intended to reawaken egg maturation and development within the ovary and potentially improve egg quality especilally in women with low egg count or women over 40.
https://ovarianresearch.biomedcentral.com/articles/10.1186/s13048-024-01423-2
Are there any studies to support Ovarian Rejuvenation?
There are OVER 150 Peer-Reviewed Publications showing that Rejuvenation Therapy could be used to achieve pregnancy in women with Low Ovarian Reserve, women with Premature Ovarian Insufficiency (POI), and women with early menopause
https://pubmed.ncbi.nlm.nih.gov/?term=PRP+and+ovaries&sort=date
Dr Merhi has helped the oldest woman in the USA get pregnant using her own eggs at age 51 by IVF following ovarian rejuvenation. RFC has helped the highest number of women in their ealry 50’s and late 40’s get pregnant using their own eggs by IVF.
What are the IVF success rates at RFC?
Rejuvenating Fertility Center’s success rates of 58% surpasses national averages of 44%. We offer tailored treatments for every patients especially those over 40 and with low ovarian reserve (low egg count): low AMH, high FSH (Follicle Stimulatig Hormone), PCOS, or those who are poor responders to conventional IVF. Since 2020, RFC has been reporting highest success rates yearly in the country with a 68% success rate for IVF with PGT and 69% for women under 35. Emphasis on affordability and personalized care is our main mission.
Our Innovative Ovarian Rejuvenation has been featured in USA Today and BUSINESS INSIDER magazines:
what are the benefits of ovarian rejuvenation, besides fertility?
Ovarian Rejuvenation can help improve hormonal imbalances or if you have menopause and have:
✨ Mood swings, anxiety, or depression
✨ Unexplained weight changes
✨ Dry or oily skin
✨ Thinning hair or hair loss
✨ Hot flashes or night sweats
✨ Low libido or vaginal dryness
✨ Sleep troubles or fatigue
What is Stem Cell Ovarian Rejuvenation and where can it be performed?
Our Breakthrough Stem Cell Ovarian Rejuvenation has been featured in TechBullion:
WHO IS A CANDIDATE FOR OVARIAN REJUVENATION:
- Low Ovarian Reserve: low AMH or high FSH levels
- Poor egg quality
- poor embryo quality
- early menopause
- Premature Ovarian Insufficiency (POI)
- hormonal imbalance
ovarian Rejuvenation is a cutting-edge fertility procedure that is still considered experimental but offers new hope to a lot of women who would like to have babies using their own genetics and eggs.
HOW MANY TYPES OF OVARIAN REJUVENATION ARE THERE?
There are 2 types of ovarian rejuvenation that can be done in the United States. There are over 150 peer-reviewed publications about ovarian rejuvenation:
https://pubmed.ncbi.nlm.nih.gov/?term=PRP+and+ovaries
Rejuvenating Fertility Center has performed extensive research over one decade and has published several high quality peer-reviewed publications
https://pubmed.ncbi.nlm.nih.gov/?term=merhi+and+prp
Why choose RFC for Ovarian Rejuvenation?
Dr Merhi was:
1. The FIRST in the NORTHEAST to offer PRP (Platelet-Rich Plasma) Ovarian Rejuvenation
2. The FIRST in the U.S.A. to offer Adipose-PRP Ovarian Rejuvenation
First type: PRP Ovarian Rejuvenation procedure:
How is the procedure performed and how long does it take?
You need to stay in the office for 1.5 hours. It is a minimally invasive vaginal procedure and you are usually given anesthesia so you will not feel any pain. The steps are:
Step 1: Come to office and we will take blood from your forearm (5 minutes)
Step 2: The blood is taken to the lab for PRP preparation (approximately 1 hour)
Step 3: The injection inside the ovaries vaginally under ultrasound guidance after the anesthesiologist makes you comfortable (25 minutes)
Following the procedure, we will ask you to monitor weekly (blood hormones + vaginal ultrasound) for 2-8 weeks. The vaginal ultrasound is also performed at the time of the blood test in order to count the number of follicles inside the ovaries.
How many PRP treatments are typically needed?
PRP lasts for up to 3 months during which patients can see improvement in egg quality and/or quality.
After 3 months, if no improvement is seen, you can either do another PRP or consider Adipose-PRP.
Can PRP be combined with IVF or other fertility treatments?
Yes. PRP is sometimes used alongside IVF or other protocols. The timing and combination depend on your treatment plan and goals. Usually we recommend it is done at least 2 weeks before IVF start.
Second Type: ADIPOSE-PRP Ovarian Rejuvenation procedure:
There are over 100 peer-reviewed publications on PubMed that have shown positive effect of Adipose Stem Cells on ovarian function.
https://pubmed.ncbi.nlm.nih.gov/?term=Adipose+stem+cells+and+ovaries
Fat is removed from the belly by mini-liposuction. The reasons RFC chose adipose (fat) are because fat:
- Is easily accessible and contains stem cells
- Has been studied in humans and proven to be safe
- Can differentiate into “new” younger eggs that can get fertilized to form embryos – allowing parents to transfer their DNA to their children
- Has low immunogenicity, meaning the body rarely tries to reject them as “foreign”
- The stem cells-containing fat is added to the PRP = “adipose + PRP” then injected inside the ovaries or the uterus.
Our Adipose-PRP has been featured in many magazines
Summary of ADIPOSE-PRP Ovarian Rejuvenation procedure:
How is ADIPOSE-PRP procedure performed and how long does it take?
You need to stay in the office for 2 hours. It is a minimally invasive vaginal procedure and you are usually given anesthesia so you will not feel any pain. The steps are:
Step 1: Come to office and we will take blood from your forearm to prepare the PRP (1 hour)
Step 2: Non-invasive mini liposuction from the belly would be performed (very tiny hole, less than 1 cm). The stem cells will be extracted from the adipose tissue and added to your PRP (approximately 35 minutes)
Step 3: The injection of the Adipose + PRP together inside the ovaries vaginally under ultrasound guidance after the anesthesiologist makes you comfortable (25 minutes)
Following the procedure, we will ask you to monitor weekly (blood hormones + vaginal ultrasound) for 2-8 weeks. The vaginal ultrasound is also performed at the time of the blood test in order to count the number of follicles inside the ovaries.
WHY OVARIAN REJUVENATION DOES NOT WORK ALL THE TIME?
Ovarian rejuvenation is still considered an emerging treatment. Outcomes vary, and success is not guaranteed. Like any treatment, PRP or Adipose-PRP might not work for everyone for unknown reasons. Some patients who did Ovarian Rejuvenation at other practices may feel that Ovarian Rejuvenation did NOT deliver the expected results. But before jumping to conclusions, it’s essential to ask a few IMPORTANT questions:
1. How was the procedure performed? Was the Ovarian Rejuvenation approach customized on my unique needs?
2. Amount of PRP or ADIPOSE-PRP injected: Did the practitioner inject enough amount in each ovary?
3. Number of injections: How many injections were administered inside each ovary?
4. Needle size: What size needle was used? Small versus large needle… technique matters.
5. Injection sites: Where exactly in the ovaries was the PRP or ADIPOSE-PRP injected? Precise placement WILL influence outcomes.
6. AFTER Ovarian Rejuvenation “medications & protocol”: What medications or protocols were given after the procedure? Proper protocol is 50% of the key to success.
Remember, success isn’t just about the procedure itself but also about personalized treatment plans, technique, and post-care.
✨ Knowledge is power when it comes to optimizing your reproductive health!
What are the side effect of ovarian rejuvenation?
Based on recent reviews, trials, and complication reports, here are possible adverse effects:
Common/expected (usually mild & short-lived)
- Pelvic cramping, spotting, transient discomfort; vasovagal symptoms after needle procedures. These mirror minor effects seen after transvaginal oocyte retrievals.
Procedure-related (rare but important)
- Infection (including pelvic/ovarian abscess); bleeding/hemoperitoneum; injury to nearby structures; anesthesia/sedation reactions. Complication rates for the analogous oocyte-retrieval procedure are low (severe ≈0.08% in one series; infections ≲0.5%), but case reports of ovarian abscess after intra-ovarian PRP exist.
PRP/product-specific
- Contamination risk during blood draw/prep if sterility lapses; local inflammation/fever have been described with PRP in other fields.
OVARIAN REJUVENATION SUCCESS RATES AND RESEARCH:
- Zaher Merhi and Marco Mouanness. Intraovarian platelet-rich plasma administration could improve blastocyst euploidy rates in women undergoing in vitro fertilization. Clin Exp Reprod Med. 2022;49:210-214.
- Zaher Merhi and Marco Mouanness. Intraovarian Platelet-Rich Plasma administration Induced Spontaneous Ovulation in an Anovulatory Woman with PCOS. JCEM Case Reports. 2023;21;1:38.
- Zaher Merhi and Marco Mouanness. Intraovarian PRP Injection Improved Hot Flashes in a Woman With Very Low Ovarian Reserve. Reprod Sci. 2022;29:614-619.
- Marco Mouanness and Zaher Merhi and. Use of Intra-uterine Injection of Platelet-rich Plasma (PRP) for Endometrial Receptivity and Thickness: a Literature Review of the Mechanisms of Action. Reprod Sci. 2021;28:1659-1670.
- Zaher Merhi and Marco Mouanness. Ovarian response to intraovarian platelet-rich plasma (PRP) administration: hypotheses and potential mechanisms of action. J Assist Reprod Genet. 2022;39:37-61.
To follow us on instagram, please visit:
https://www.instagram.com/rejuvenatingfertilitycenter?igsh=aWQ4bm5zOW5wOHRw&utm_source=qr