Uterine Rejuvenation
(PRP or Adipose-PRP)
If you struggle with Recurrent Implantation Failure (RIF), Recurrent Miscarriages or Chemical Pregnancies, Uterine Rejuvenation is for you
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RFC is one of the first centers in the world to pioneer and publish about PRP rejuvenation.
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We help women who weren told that they cannot carry a pregnancy and need "surrogacy/gestational carrier."
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As of today, there are over 170 medical publications about PRP administration and reproduction.
What is uterine rejuvenation?
Uterine rejuvenation is a regenerative medicine approach in which a patient’s own platelet-rich plasma (PRP) or Adipose (fat)-PRP in combination are used with the goal of:
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Improving endometrial thickness and quality
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Enhancing blood flow and tissue repair
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Supporting endometrial receptivity
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Reducing inflammation in selected patients
What is PRP?
PRP stands for platelet-rich plasma, a concentrated component of your own blood that contains growth factors. In ovarian rejuvenation, PRP is carefully prepared and delivered to the uterus via infusion or injections (under hysteroscopy guidance) approach.
What is Adipose?
Adipose stands for fat and it contains high amount of regenerative mesenchymal stem cells. It is combined with PRP then administered into the uterine lining for rejuvenation purposes.
The goal is to support your uterus for implantation and to lower miscarriage and chemical pregnancy risks.
Who is a candidate for uterine rejuvenation?
Uterine rejuvenation is an adjunctive regenerative therapy using PRP or Adipose-PRP intended to support endometrial health in selected patients. It is not a replacement for standard fertility treatments and does not guarantee pregnancy.
Women who have:
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Persistently thin endometrial lining despite estrogen therapy
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Poor endometrial growth in prior natural or medicated cycles
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History of cancelled embryo transfers due to inadequate lining
PRP or Adipose-PRP may help by promoting local growth factors, angiogenesis, and tissue repair.
Women with:
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Multiple failed embryo transfers of good-quality or euploid embryos
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No clear anatomic or infectious cause identified
PRP or Adipose-PRP may improve endometrial receptivity in select cases.
Including patients with:
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Prior uterine surgery (D&C, myomectomy, ablation-related injury)
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History of postpartum or post-procedure infection affecting the endometrium
PRP or Adipose-PRP may support tissue regeneration in damaged endometrium.
4. Chronic Endometrial Inflammation
Patients with:
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Persistent symptoms or suboptimal endometrial environment
PRP or Adipose-PRP may help restore endometrial health once infection is cleared.
5. Advanced Reproductive Age or Reproductive Aging
Women who:
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Are of advanced reproductive age
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Show signs of endometrial aging despite otherwise normal uterine anatomy
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Are pursuing embryo transfer with own or donor embryos
PRP or Adipose-PRP are considered a biologic optimization strategy, not a fertility guarantee.
6. Patients Seeking Regenerative or Longevity-Focused Gynecologic Care
Women who:
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Are interested in regenerative medicine approaches
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Have gynecologic symptoms potentially linked to endometrial health
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Are part of a broader longevity or uterine health optimization program
This includes patients not actively trying to conceive, when used cautiously and with appropriate counseling.
Who Is Not an Ideal Candidate for uterine rejuvenation?
It is not recommended for patients with:
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Active uterine or pelvic infection
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Untreated uterine pathology (polyps, fibroids distorting the cavity)
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Endometrial cancer or precancerous lesions
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Significant uterine malformations
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Unrealistic expectations of guaranteed success
PRP uterine rejuvenation:
How is the procedure performed?
PRP can be delivered in two main ways (RFC doctors will counsel you about which one you need):
A) PRP Uterine Infusion
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PRP is gently infused into the uterine cavity using a thin catheter
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Similar to an embryo transfer
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Performed in the office without anesthesia
B) PRP Endometrial Injection (Hysteroscopic-Guided)
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PRP is injected directly into targeted areas of the endometrial lining
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Performed under hysteroscopic visualization
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Usually requires sedation or anesthesia
OR
Procedure timeline (in-office)
Most patients spend about 1.5 hours at the clinic.
PRP preparation (about 40 minutes)
We draw a small amount of blood from your arm, and your blood is processed in a controlled setting to concentrate platelets.
PRP Infusion
(about 5 minutes)
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The patient lies in a standard gynecologic exam position
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A thin, soft embryo-transfer catheter is gently passed through the cervix into the uterine cavity
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1–2 mL of PRP is slowly infused into the uterus
PRP Injections
(about 30 minutes)
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A specialized hysteroscopic injection needle is passed through the working channel of the hysteroscope
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PRP is injected into the subendometrial or superficial myometrial layer, typically: At multiple sites and along the anterior and posterior uterine walls
What happens after uterine PRP administration?
A) For PRP Uterine Infusion:
PRP's effect starts within 24 hours and last only for that one particular cycle during which patients undergo an embryo transfer cycle.
B) For PRP Endometrial Injection (By Hysteroscopy):
PRP's effect starts within couple of weeks and can last up to ~3 months during which patients undergo an embryo transfer cycle.
If meaningful improvement is not seen, your physician may discuss next steps, including repeating PRP or considering other options such as Adipose-PRP or Stem cells in the Bahamas.
Why PRP uterine rejuvenation is different at RFC?
RFC has been one of the first pioneers worldwide to master and offer PRP uterine rejuvenation which is highly technique-dependent and response varies among different clinics.
Common reasons for variable outcomes include:
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PRP preparation: quality and concentration
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Injection location: within the lining of the uterus
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Injection techniques: size of the needle and number of injections
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Post-procedure: protocol and monitoring
At RFC, we emphasize case selection + technique + post-care protocol, not just the procedure.
Safety & Limitations
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Uses the patient’s own blood, minimizing allergic risk
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Generally well tolerated when performed properly
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Infection risk is low but not zero
We review risks, safety steps, and individualized contraindications during your consultation
Adipose-PRP uterine rejuvenation:
How is the procedure performed?
Adipose-PRP uterine rejuvenation at RFC is designed for difficult cases.
Adipose stem cells are more superior for the lining oof the uturus than other types of stem cells.
Adipose-PRP ovarian rejuvenation combines two autologous biologic components:
Platelet-Rich Plasma (PRP)
Derived from your blood
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Adipose-derived regenerative cells
Obtained from a small fat sample
Adipose-PRP Is Performend Only as Endometrial Injection (Hysteroscopic-Guided)
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Adipose-PRP is injected directly into targeted areas of the endometrial lining
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Performed under hysteroscopic visualization
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Usually requires sedation or anesthesia
PRP preparation (≈40 minutes)
Blood is drawn from the arm and processed to prepare platelet-rich plasma.
Mini liposuction (≈30 minutes)
A small amount of fat is gently collected from the abdomen through a tiny entry point (usually <1 cm). Regenerative cells are extracted from the adipose tissue.
Combination + delivery (≈20 minutes)
The adipose-derived regenerative component is combined with PRP and injected intra-ovarianly under ultrasound guidance (and in select cases, intra-uterine), with anesthesia and comfort measures provided.
Most patients spend approximately 2 hours at the clinic.
What happens after uterine Adipose-PRP administration?
Adipose-PRP's effect starts within couple of weeks and can last up to ~6 months during which patients undergo an embryo transfer cycle.
If meaningful improvement is not seen, your physician may discuss next steps, including Stem cells in the Bahamas.
Why choose RFC for uterine rejuvenation?
RFC is known for personalized fertility care for women with complex profiles—especially those Recurrent Implantation Failure (RIP) and Recurrent Miscarriage. Our team emphasizes:
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Pioneers in PRP and Adipose-PRP preparation and administration
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Research participation and ongoing publication
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Global care experience (many patients travel for treatment)
UTERINE REJUVENATION SUCCESS RATES AND RESEARCH FROM RFC:
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Marco Mouanness and Zaher Merhi and. Use of Intra-uterine Injection of Platelet-rich Plasma (PRP) for Endometrial Receptivity and Thickness: a Literature Review of the Mechanisms of Action. Reprod Sci. 2021;28:1659-1670.
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Zaher Merhi, Catrina Wiltshire McLeod, Fawziyah Shamim. Platelet-Rich Plasma in Reproductive Endocrinology: Mechanisms and Clinical Applications for Ovarian Reserve, PCOS, and Endometrial Receptivity. Biomedicines. 2025 Oct 13;13(10):2488.
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Zaher Merhi. Clinical practice perspectives on adipose-derived stem cells and platelet-rich plasma for female infertility treatments. Future Sci OA. 2025 Dec;11(1):2580233.
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Zaher Merhi, Bhavika Garg, Jessica Haroun. Endocrine and regenerative mechanisms of adipose-derived stem cells in female infertility. Front Endocrinol (Lausanne). 2025 Oct 21:16:1694025