World Exclusive · RFC Flagship Protocol
Advanced Ovarian Rejuvenation in USA
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Three regenerative therapies.
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One single procedure.
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Available in USA locations and in our Nassau, the Bahamas location.
If you've been told your ovarian reserve is too low or your eggs are no longer viable — even after PRP or Adipose-PRP — Advanced Ovarian Rejuvenation may offer a final, more intensive option to pursue pregnancy with your own eggs.
✅ The FIRST and ONLY clinic in the world to combine all three therapies in a single procedure
✅ Combines 1) PRP + 2) Adipose Tissue containing Stem Cells + 3) Bone Marrow containing Stem Cells
✅ Reported pregnancies in women over 45 using their own eggs after the protocol
From PRP to Adipose to Bone Marrow... to Advanced
RFC pioneered ovarian rejuvenation in the United States and continues to lead its evolution. Each tier builds on the last — and Advanced Ovarian Rejuvenation represents the most comprehensive regenerative protocol we offer.
Bone Marrow-PRP
Ovarian Rejuvenation
PRP combined with regenerative stem cells from your own Bone Marrow stem cells.
Components 2 (Bone Marrow containing stem cells + PRP)
Where offered USA + Bahamas
Time at clinic ~2 hrs
Adipose (fat)-PRP
Ovarian Rejuvenation
PRP combined with regenerative stem cells from your own fat tissue. RFC was the first in the world to publish live births in women over 45 using this protocol.
Components 2 (Adipose + PRP)
Where offered USA + Bahamas
Time at clinic ~2 hrs
PRP Ovarian Rejuvenation
Platelet-rich plasma alone, drawn from your blood and delivered directly to the ovaries. RFC was the first in the Northeast to pioneer this approach.
Components 1 (PRP)
Where offered USA + Bahamas
Time at clinic ~1.5 hrs
Advanced Ovarian Rejuvenation (all 3 together)
All 3 regenerative therapies — PRP, Adipose containing stem cells, and Bone Marrow containing stem cells — combined and delivered in a single procedure. The most intensive protocol RFC offers.
Components 3 (All combined)
Where offered USA + Bahamas
Time at clinic ~2.5 hrs
Super Ovarian Rejuvenation in Bahamas Only
4 regenerative therapies in 1 single procedure.
No other clinic in the world combines these four biologic components in one procedure. Each contributes a distinct mechanism — together, they're delivered directly to the ovaries during the same visit.
1) Platelet-Rich Plasma (PRP)
Concentrated platelets from the patient's own blood — a dense source of growth factors that have been shown to support follicular activity in over 170 published studies.
2) Adipose containing Stem Cells
Fat-derived regenerative cells, harvested via mini-liposuction from the patient's own abdomen — autologous, well-studied, and rich in mesenchymal stem cells.
3) Bone Marrow containing Stem Cells
Mesenchymal stem cells used to support ovarian tissue regeneration and reawaken dormant follicles in the ovarian environment.
4) Umbilical Cord Stem Cells/Exosomes
Microscopic vesicles that carry cell-signaling molecules — they amplify communication between cells and support tissue repair beyond what stem cells deliver alone.
Who is a candidate for Advanced or Super Ovarian Rejuvenation?
Advanced Ovarian Rejuvenation is designed for women who want to pursue pregnancy with their own eggs and have not seen sufficient improvement from standard PRP or Adipose-PRP. Most candidates fall into one of these categories:
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Women 40–55 with very low or Zero AMH
Diminished ovarian reserve (DOR) — including women whose AMH reads as zero — who want to pursue pregnancy using their own eggs.
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Prior PRP or Adipose-PRP non-responders
Women who have already undergone PRP or Adipose-PRP ovarian rejuvenation and did'nt see meaningful improvement in ovarian response.
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Premature ovarian insufficiency (POI)
Women diagnosed with POI or early menopause who wish to explore the most comprehensive regenerative option before considering donor eggs.
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Repeated IVF failures with poor response
Women with multiple prior IVF cycles showing poor ovarian response or poor egg/embryo quality despite optimized stimulation.
The Super Ovarian Rejuvenation procedure (exclusively in the Bahamas)
All four therapies are prepared and delivered during a single visit at our Nassau, Bahamas location. Most patients spend approximately 2.5 hours at the clinic.
Built on RFC's published ovarian rejuvenation research
Advanced Ovarian Rejuvenation builds directly on RFC's foundational work in PRP and adipose-based ovarian rejuvenation — research published across leading peer-reviewed journals over the past several years.
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Zaher Merhi and Marco Mouanness. Intraovarian platelet-rich plasma administration could improve blastocyst euploidy rates in women undergoing in vitro fertilization. Clin Exp Reprod Med. 2022;49:210-214.
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Zaher Merhi and Marco Mouanness. Intraovarian Platelet-Rich Plasma administration Induced Spontaneous Ovulation in an Anovulatory Woman with PCOS. JCEM Case Reports. 2023;21;1:38.
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Zaher Merhi and Marco Mouanness. Intraovarian PRP Injection Improved Hot Flashes in a Woman With Very Low Ovarian Reserve. Reprod Sci. 2022;29:614-619.
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Marco Mouanness and Zaher Merhi and. Use of Intra-uterine Injection of Platelet-rich Plasma (PRP) for Endometrial Receptivity and Thickness: a Literature Review of the Mechanisms of Action. Reprod Sci. 2021;28:1659-1670.
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Zaher Merhi and Marco Mouanness. Ovarian response to intraovarian platelet-rich plasma (PRP) administration: hypotheses and potential mechanisms of action. J Assist Reprod Genet. 2022;39:37-61.